Synthesis and characterization of some new derivatives from 6- methyl 2-thiouracil

This research, involved synthesis of a series of new compound containing different derivatives. The synthesis involved treatment of 6methyl 2-thiouracil with chloroacetyl chloride to give 1chloroacetyl 6methyl 2-thiouracil (1) .The product was treat with hydrazine hydrate to give 2( aceto hydrazide ) thiouracil (2), and with phenyl hydrazine to give phenyl hydrazide thiouracil (13). The new derivatives (3-12, 1423) were synthesized by reaction of the hydazide and phenyl hydrazide derivatives (2, 13) with different aromatic aldehydes in the presence of glacial acetic acid. The structure of all the prepared compounds confirmation were proved using (FTIR), ( 1 H –NMR) and in addition to melting point.